产品货号：
Z28484
中文名称：
TMEM38B抗体
英文名称：
Anti-TMEM38B Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TMEM38B Antibody |
| 指标别名 | OI14;TRICB;TRIC-B;C9orf87;D4Ertd89e;bA219P18.1;Trimeric intracellular cation channel type B;Transmembrane protein 38B |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | TMEM38B |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | TMEM38B antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38B.The immunogen is located within the last 50 amino acids of TMEM38B. |
| 计算分子量 | 33kDa |
| 成分 | TMEM38B Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | TMEM38B Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes.TMEM38B is expressed in most mammalian tissues,while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain.Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure;the cardiac myocytes display severe dysfunction in SR Ca2+ handling,weakened Ca2+ release,and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores.Mice that were lacking only TMEM38B however,die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells,indicating that TMEM38B are essential for perinatal lung maturation.Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells. |
| Uniprot ID | Q9NVV0 |
| 基因名全称 | Transmembrane protein 38B |
| 蛋白名全称 | Transmembrane protein 38B |
| 推荐稀释比 | TMEM38B antibody can be used for detection of TMEM38B by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in rat samples;Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples.All other applications and species not yet tested. |
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